Modulating the DNA polymerase β reaction equilibrium to dissect the reverse reaction

DNA polymerases catalyze efficient and high fidelity DNA synthesis. While this reaction favors nucleotide incorporation, polymerases also catalyze a reverse reaction, pyrophosphorolysis, removing the DNA primer terminus and generating deoxynucleoside triphosphates. Since pyrophosphorolysis can influ...

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Detalles Bibliográficos
Autores principales: Shock, David D., Freudenthal, Bret D., Beard, William A., Wilson, Samuel H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605435/
https://www.ncbi.nlm.nih.gov/pubmed/28759020
http://dx.doi.org/10.1038/nchembio.2450

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605435/
https://www.ncbi.nlm.nih.gov/pubmed/28759020
http://dx.doi.org/10.1038/nchembio.2450

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