Type I IFNs and TNF cooperatively reprogram the macrophage epigenome to promote inflammatory activation

Cross-regulation of Toll-like receptor responses by cytokines is essential for effective host defense, avoidance of toxicity, and homeostasis, but the underlying mechanisms are not well understood. A comprehensive epigenomic approach in human macrophages showed that the proinflammatory cytokines TNF...

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Detalles Bibliográficos
Autores principales: Park, Sung Ho, Kang, Kyuho, Giannopoulou, Eugenia, Qiao, Yu, Kang, Keunsoo, Kim, Geonho, Park-Min, Kyung-Hyun, Ivashkiv, Lionel B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605457/
https://www.ncbi.nlm.nih.gov/pubmed/28825701
http://dx.doi.org/10.1038/ni.3818

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605457/
https://www.ncbi.nlm.nih.gov/pubmed/28825701
http://dx.doi.org/10.1038/ni.3818

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