Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis

Group 2 innate lymphoid cells (ILC2s) are involved in human diseases, such as allergy, atopic dermatitis and nasal polyposis, but their function in human cancer remains unclear. Here we show that, in acute promyelocytic leukaemia (APL), ILC2s are increased and hyper-activated through the interaction...

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Detalles Bibliográficos
Autores principales: Trabanelli, Sara, Chevalier, Mathieu F., Martinez-Usatorre, Amaia, Gomez-Cadena, Alejandra, Salomé, Bérengère, Lecciso, Mariangela, Salvestrini, Valentina, Verdeil, Grégory, Racle, Julien, Papayannidis, Cristina, Morita, Hideaki, Pizzitola, Irene, Grandclément, Camille, Bohner, Perrine, Bruni, Elena, Girotra, Mukul, Pallavi, Rani, Falvo, Paolo, Leibundgut, Elisabeth Oppliger, Baerlocher, Gabriela M., Carlo-Stella, Carmelo, Taurino, Daniela, Santoro, Armando, Spinelli, Orietta, Rambaldi, Alessandro, Giarin, Emanuela, Basso, Giuseppe, Tresoldi, Cristina, Ciceri, Fabio, Gfeller, David, Akdis, Cezmi A., Mazzarella, Luca, Minucci, Saverio, Pelicci, Pier Giuseppe, Marcenaro, Emanuela, McKenzie, Andrew N. J., Vanhecke, Dominique, Coukos, George, Mavilio, Domenico, Curti, Antonio, Derré, Laurent, Jandus, Camilla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605498/
https://www.ncbi.nlm.nih.gov/pubmed/28928446
http://dx.doi.org/10.1038/s41467-017-00678-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605498/
https://www.ncbi.nlm.nih.gov/pubmed/28928446
http://dx.doi.org/10.1038/s41467-017-00678-2

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