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Activation of miR-34a-5p/Sirt1/p66shc pathway contributes to doxorubicin-induced cardiotoxicity

The molecular mechanisms underlying anthracyclines-induced cardiotoxicity have not been well elucidated. MiRNAs were revealed dysregulated in the myocardium and plasma of rats received Dox treatment. MicroRNA-34a-5p (miR-34a-5p) was verified increased in the myocardium and plasma of Dox-treated rats...

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Detalles Bibliográficos
Autores principales: Zhu, Jie-Ning, Fu, Yong-Heng, Hu, Zhi-qin, Li, Wen-Yu, Tang, Chun-Mei, Fei, Hong-Wen, Yang, Hui, Lin, Qiu-xiong, Gou, De-Ming, Wu, Shu-Lin, Shan, Zhi-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605522/
https://www.ncbi.nlm.nih.gov/pubmed/28928469
http://dx.doi.org/10.1038/s41598-017-12192-y