Agonist immunotherapy restores T cell function following MEK inhibition improving efficacy in breast cancer

The presence of tumor-infiltrating lymphocytes in triple-negative breast cancers is correlated with improved outcomes. Ras/MAPK pathway activation is associated with significantly lower levels of tumor-infiltrating lymphocytes in triple-negative breast cancers and while MEK inhibition can promote re...

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Detalles Bibliográficos
Autores principales: Dushyanthen, Sathana, Teo, Zhi Ling, Caramia, Franco, Savas, Peter, Mintoff, Christopher P., Virassamy, Balaji, Henderson, Melissa A., Luen, Stephen J., Mansour, Mariam, Kershaw, Michael H., Trapani, Joseph A., Neeson, Paul J., Salgado, Roberto, McArthur, Grant A., Balko, Justin M., Beavis, Paul A., Darcy, Phillip K., Loi, Sherene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605577/
https://www.ncbi.nlm.nih.gov/pubmed/28928458
http://dx.doi.org/10.1038/s41467-017-00728-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605577/
https://www.ncbi.nlm.nih.gov/pubmed/28928458
http://dx.doi.org/10.1038/s41467-017-00728-9

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