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Peripheral Autoimmune Regulator Induces Exhaustion of CD4(+) and CD8(+) Effector T Cells to Attenuate Autoimmune Diabetes in Non-Obese Diabetic Mice
Autoimmune regulator (Aire) is one of the most crucial genes expressed in the thymus, where it orchestrates the promiscuous expression and presentation of tissue-specific antigens during thymocyte selection. The presence of Aire-expressing cells outside the thymus points toward its plausible extrath...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605615/ https://www.ncbi.nlm.nih.gov/pubmed/28966617 http://dx.doi.org/10.3389/fimmu.2017.01128 |