A comprehensive characterization of PncA polymorphisms that confer resistance to pyrazinamide

Tuberculosis chemotherapy is dependent on the use of the antibiotic pyrazinamide, which is being threatened by emerging drug resistance. Resistance is mediated through mutations in the bacterial gene pncA. Methods for testing pyrazinamide susceptibility are difficult and rarely performed, and this m...

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Detalles Bibliográficos
Autores principales: Yadon, Adam N., Maharaj, Kashmeel, Adamson, John H., Lai, Yi-Pin, Sacchettini, James C., Ioerger, Thomas R., Rubin, Eric J., Pym, Alexander S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605632/
https://www.ncbi.nlm.nih.gov/pubmed/28928454
http://dx.doi.org/10.1038/s41467-017-00721-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605632/
https://www.ncbi.nlm.nih.gov/pubmed/28928454
http://dx.doi.org/10.1038/s41467-017-00721-2

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