Cargando…

Ang-(1-7) is an endogenous β-arrestin-biased agonist of the AT(1) receptor with protective action in cardiac hypertrophy

The renin-angiotensin system (RAS) plays a key role in the control of vasoconstriction as well as sodium and fluid retention mediated mainly by angiotensin (Ang) II acting at the AT(1) receptor (AT1R). Ang-(1-7) is another RAS peptide, identified as the endogenous ligand of the Mas receptor and know...

Descripción completa

Detalles Bibliográficos
Autores principales:	Teixeira, Larissa B., Parreiras-e-Silva, Lucas T., Bruder-Nascimento, Thiago, Duarte, Diego A., Simões, Sarah C., Costa, Rafael M., Rodríguez, Deisy Y., Ferreira, Pedro A. B., Silva, Carlos A. A., Abrao, Emiliana P., Oliveira, Eduardo B., Bouvier, Michel, Tostes, Rita C., Costa-Neto, Claudio M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605686/ https://www.ncbi.nlm.nih.gov/pubmed/28928410 http://dx.doi.org/10.1038/s41598-017-12074-3

Ejemplares similares

Comparative analyses of downstream signal transduction targets modulated after activation of the AT(1) receptor by two β-arrestin-biased agonists
por: Santos, Geisa A., et al.
Publicado: (2015)

Signal Transduction Profiling of Angiotensin II Type 1 Receptor With Mutations Associated to Atrial Fibrillation in Humans
por: Simões, Sarah C., et al.
Publicado: (2020)

Ang II Promotes Cardiac Autophagy and Hypertrophy via Orai1/STIM1
por: Zheng, Chang-Bo, et al.
Publicado: (2021)

β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility
por: Kim, Jihee, et al.
Publicado: (2018)

Non-neutralizing antibodies increase endogenous circulating Ang1 levels
por: Zheng, Chao, et al.
Publicado: (2018)

Enhanced Mutant Compensates for Defects in Rhodopsin Phosphorylation in the Presence of Endogenous Arrestin-1
por: Samaranayake, Srimal, et al.
Publicado: (2018)

The involvement of aldosterone on vascular insulin resistance: implications in obesity and type 2 diabetes
por: Bruder-Nascimento, Thiago, et al.
Publicado: (2014)

Role of Renin-Angiotensin System Components in Atherosclerosis: Focus on Ang-II, ACE2, and Ang-1–7
por: Silva, Gabriela M., et al.
Publicado: (2020)

Pharmacological Characterization of 5-Substituted 1-[(2,3-dihydro-1-benzofuran-2-yl)methyl]piperazines: Novel Antagonists for the Histamine H(3) and H(4) Receptors with Anti-inflammatory Potential
por: Corrêa, Michelle F., et al.
Publicado: (2017)

Caspase-1 regulates Ang II-induced cardiomyocyte hypertrophy via up-regulation of IL-1β
por: Bai, Yunlong, et al.
Publicado: (2018)

Effect of ligustilide on Ang II-induced hypertrophy in cardiomyocytes and the potential mechanisms
por: LU, QUN, et al.
Publicado: (2014)

Evaluation of Functional Selectivity of Haloperidol, Clozapine, and LASSBio-579, an Experimental Compound With Antipsychotic-Like Actions in Rodents, at G Protein and Arrestin Signaling Downstream of the Dopamine D(2) Receptor
por: Silva, Rafaela R., et al.
Publicado: (2019)

Novel Therapeutic Effects of Pterosin B on Ang II-Induced Cardiomyocyte Hypertrophy
por: Lee, Chang Youn, et al.
Publicado: (2020)

Comparative evaluation of biased agonists Sarcosine(1), d‐Alanine (8) ‐Angiotensin (Ang) II (SD Ang II) and Sarcosine(1), Isoleucine (8) ‐Ang II (SI Ang II) and their radioiodinated congeners binding to rat liver membrane AT(1) receptors
por: Noto, Natalia M., et al.
Publicado: (2023)

EPC-Derived Microvesicles Protect Cardiomyocytes from Ang II-Induced Hypertrophy and Apoptosis
por: Gu, Shenhong, et al.
Publicado: (2014)

Cardioprotective effects of Moku-boi-to and its impact on AngII-induced cardiomyocyte hypertrophy
por: Tagashira, Hideaki, et al.
Publicado: (2023)

Mouse Sirt3 promotes autophagy in AngII-induced myocardial hypertrophy through the deacetylation of FoxO1
por: Li, Jingyuan, et al.
Publicado: (2016)

Physiological and pathological roles of Ang II and Ang- (1-7) in the female reproductive system
por: Liu, Yuanyuan, et al.
Publicado: (2022)

Progranulin Maintains Blood Pressure and Vascular Tone Dependent on EphrinA2 and Sortilin1 Receptors and Endothelial Nitric Oxide Synthase Activation
por: Bruder‐Nascimento, Ariane, et al.
Publicado: (2023)

Correction: Mouse Sirt3 promotes autophagy in AngII-induced myocardial hypertrophy through the deacetylation of FoxO1
por: Li, Jingyuan, et al.
Publicado: (2022)

Development of nonfibrotic left ventricular hypertrophy in an ANG II‐induced chronic ovine hypertension model
por: Klatt, Niklas, et al.
Publicado: (2016)

Scoparone alleviates Ang II‐induced pathological myocardial hypertrophy in mice by inhibiting oxidative stress
por: Lyu, Linmao, et al.
Publicado: (2021)

Angiotensin (1-7) Inhibits Ang II-mediated ERK1/2 Activation by Stimulating MKP-1 Activation in Vascular Smooth Muscle Cells
por: Sousa-Lopes, Alejandra, et al.
Publicado: (2020)

Ang1 and Ang4 differentially affect colitis and carcinogenesis in an AOM-DSS mouse model
por: Hu, Alexander, et al.
Publicado: (2023)

Spironolactone treatment attenuates vascular dysfunction in type 2 diabetic mice by decreasing oxidative stress and restoring NO/GC signaling
por: Silva, Marcondes A. B., et al.
Publicado: (2015)

β-Arrestin1 and β-Arrestin2 Are Required to Support the Activity of the CXCL12/HMGB1 Heterocomplex on CXCR4
por: D’Agostino, Gianluca, et al.
Publicado: (2020)

The protective effects of the miR-129-5p/keap-1/Nrf2 axis on Ang II-induced cardiomyocyte hypertrophy
por: Ye, Huiming, et al.
Publicado: (2021)

LSD-stimulated behaviors in mice require β-arrestin 2 but not β-arrestin 1
por: Rodriguiz, Ramona M., et al.
Publicado: (2021)

Internalization of Heterologous Sugar Transporters by Endogenous α-Arrestins in the Yeast Saccharomyces cerevisiae
por: Sen, Arpita, et al.
Publicado: (2016)

Michel-Ange
por: Huyghe, René

TNF-α induces vascular insulin resistance via positive modulation of PTEN and decreased Akt/eNOS/NO signaling in high fat diet-fed mice
por: da Costa, Rafael Menezes, et al.
Publicado: (2016)

Activation of Bone Marrow-Derived Cells Angiotensin (Ang) II Type 1 Receptor by Ang II Promotes Atherosclerotic Plaque Vulnerability
por: Pellegrin, Maxime, et al.
Publicado: (2018)

Arrestin-like proteins mediate ubiquitination and endocytosis of the yeast metal transporter Smf1
por: Nikko, Elina, et al.
Publicado: (2008)

Non-Coding RNAs in the Therapeutic Landscape of Pathological Cardiac Hypertrophy
por: Silva, Joana, et al.
Publicado: (2022)

Association of markers of endothelial dysregulation Ang1 and Ang2 with acute kidney injury in critically ill patients
por: Robinson-Cohen, Cassianne, et al.
Publicado: (2016)

Plasma Ang2 and ADAM17 levels are elevated during clinical malaria; Ang2 level correlates with severity and expression of EPCR-binding PfEMP1
por: Petersen, Jens E. V., et al.
Publicado: (2016)

Cannabinoid 1 (CB(1)) receptor arrestin subtype‐selectivity and phosphorylation dependence
por: Manning, Jamie J., et al.
Publicado: (2022)

Upregulation of Nrf2 and Decreased Redox Signaling Contribute to Renoprotective Effects of Chemerin Receptor Blockade in Diabetic Mice
por: Neves, Karla Bianca, et al.
Publicado: (2018)

Beta-arrestin 1 regulation of reward-motivated behaviors and glutamatergic function
por: Mittal, Nitish, et al.
Publicado: (2017)

The Role of Arrestin-1 Middle Loop in Rhodopsin Binding
por: Vishnivetskiy, Sergey A., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_f1s1egmsf55rn7a32j8bkqpf58