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Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells
BACKGROUND: Pancreatic β cell dysfunction and death are central in the pathogenesis of most if not all forms of diabetes. Understanding the molecular mechanisms underlying β cell failure is important to develop β cell protective approaches. SCOPE OF REVIEW: Here we review the role of endoplasmic ret...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605732/ https://www.ncbi.nlm.nih.gov/pubmed/28951826 http://dx.doi.org/10.1016/j.molmet.2017.06.001 |