Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells

BACKGROUND: Pancreatic β cell dysfunction and death are central in the pathogenesis of most if not all forms of diabetes. Understanding the molecular mechanisms underlying β cell failure is important to develop β cell protective approaches. SCOPE OF REVIEW: Here we review the role of endoplasmic ret...

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Detalles Bibliográficos
Autores principales: Cnop, Miriam, Toivonen, Sanna, Igoillo-Esteve, Mariana, Salpea, Paraskevi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605732/
https://www.ncbi.nlm.nih.gov/pubmed/28951826
http://dx.doi.org/10.1016/j.molmet.2017.06.001

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