Overexpression of Chromosome 21 miRNAs May Affect Mitochondrial Function in the Hearts of Down Syndrome Fetuses

Dosage-dependent upregulation of most of chromosome 21 (Hsa21) genes has been demonstrated in heart tissues of fetuses with Down syndrome (DS). Also miRNAs might play important roles in the cardiac phenotype as they are highly expressed in the heart and regulate cardiac development. Five Hsa21 miRNA...

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Detalles Bibliográficos
Autores principales: Izzo, Antonella, Manco, Rosanna, de Cristofaro, Tiziana, Bonfiglio, Ferdinando, Cicatiello, Rita, Mollo, Nunzia, Martino, Marco De, Genesio, Rita, Zannini, Mariastella, Conti, Anna, Nitsch, Lucio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605795/
https://www.ncbi.nlm.nih.gov/pubmed/29057256
http://dx.doi.org/10.1155/2017/8737649

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605795/
https://www.ncbi.nlm.nih.gov/pubmed/29057256
http://dx.doi.org/10.1155/2017/8737649

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