Cargando…

Overexpression of Chromosome 21 miRNAs May Affect Mitochondrial Function in the Hearts of Down Syndrome Fetuses

Dosage-dependent upregulation of most of chromosome 21 (Hsa21) genes has been demonstrated in heart tissues of fetuses with Down syndrome (DS). Also miRNAs might play important roles in the cardiac phenotype as they are highly expressed in the heart and regulate cardiac development. Five Hsa21 miRNA...

Descripción completa

Detalles Bibliográficos
Autores principales:	Izzo, Antonella, Manco, Rosanna, de Cristofaro, Tiziana, Bonfiglio, Ferdinando, Cicatiello, Rita, Mollo, Nunzia, Martino, Marco De, Genesio, Rita, Zannini, Mariastella, Conti, Anna, Nitsch, Lucio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605795/ https://www.ncbi.nlm.nih.gov/pubmed/29057256 http://dx.doi.org/10.1155/2017/8737649

Ejemplares similares

Mitochondrial dysfunction in down syndrome: molecular mechanisms and therapeutic targets
por: Izzo, Antonella, et al.
Publicado: (2018)

Chromosomal Microarray Analysis versus Karyotyping in Fetuses with Increased Nuchal Translucency
por: Cicatiello, Rita, et al.
Publicado: (2019)

Targeting Mitochondrial Network Architecture in Down Syndrome and Aging
por: Mollo, Nunzia, et al.
Publicado: (2020)

Overexpression of the Hsa21 Transcription Factor RUNX1 Modulates the Extracellular Matrix in Trisomy 21 Cells
por: Mollo, Nunzia, et al.
Publicado: (2022)

Pioglitazone Improves Mitochondrial Organization and Bioenergetics in Down Syndrome Cells
por: Mollo, Nunzia, et al.
Publicado: (2019)

Corrigendum: Pioglitazone Improves Mitochondrial Organization and Bioenergetics in Down Syndrome Cells
por: Mollo, Nunzia, et al.
Publicado: (2020)

Human Trisomic iPSCs from Down Syndrome Fibroblasts Manifest Mitochondrial Alterations Early during Neuronal Differentiation
por: Mollo, Nunzia, et al.
Publicado: (2021)

Altered expression of mitochondrial and extracellular matrix genes in the heart of human fetuses with chromosome 21 trisomy
por: Conti, Anna, et al.
Publicado: (2007)

Identification of Novel Pax8 Targets in FRTL-5 Thyroid Cells by Gene Silencing and Expression Microarray Analysis
por: Di Palma, Tina, et al.
Publicado: (2011)

Genetics and Molecular Basis of Congenital Heart Defects in Down Syndrome: Role of Extracellular Matrix Regulation
por: Mollo, Nunzia, et al.
Publicado: (2023)

Prenatally diagnosed distal 16p11.2 microdeletion with a novel association with congenital diaphragmatic hernia: a case report
por: Genesio, Rita, et al.
Publicado: (2018)

Down Syndrome Fetal Fibroblasts Display Alterations of Endosomal Trafficking Possibly due to SYNJ1 Overexpression
por: De Rosa, Laura, et al.
Publicado: (2022)

Short stature and primary ovarian insufficiency possibly due to chromosomal position effect in a balanced X;1 translocation
por: Genesio, Rita, et al.
Publicado: (2015)

Comparative genomics reveals a functional thyroid-specific element in the far upstream region of the PAX8 gene
por: Nitsch, Roberto, et al.
Publicado: (2010)

A role for PAX8 in the tumorigenic phenotype of ovarian cancer cells
por: Di Palma, Tina, et al.
Publicado: (2014)

PAX8 expression in high-grade serous ovarian cancer positively regulates attachment to ECM via Integrin β3
por: Soriano, Amata Amy, et al.
Publicado: (2019)

Candidate genes and pathways downstream of PAX8 involved in ovarian high-grade serous carcinoma
por: de Cristofaro, Tiziana, et al.
Publicado: (2016)

Long Non-Coding RNA HAND2-AS1 Acts as a Tumor Suppressor in High-Grade Serous Ovarian Carcinoma
por: Gokulnath, Priyanka, et al.
Publicado: (2020)

Long Non-Coding RNA MAGI2-AS3 is a New Player with a Tumor Suppressive Role in High Grade Serous Ovarian Carcinoma
por: Gokulnath, Priyanka, et al.
Publicado: (2019)

Pure 16q21q22.1 deletion in a complex rearrangement possibly caused by a chromothripsis event
por: Genesio, Rita, et al.
Publicado: (2013)

Constitutional chromothripsis involving the critical region of 9q21.13 microdeletion syndrome
por: Genesio, Rita, et al.
Publicado: (2015)

Lithium chloride induces mesenchymal-to-epithelial reverting transition in primary colon cancer cell cultures
por: COSTABILE, VALERIA, et al.
Publicado: (2015)

PAX8 as a Potential Target for Ovarian Cancer: What We Know so Far
por: Di Palma, Tina, et al.
Publicado: (2022)

In vivo role of different domains and of phosphorylation in the transcription factor Nkx2-1
por: Silberschmidt, Daniel, et al.
Publicado: (2011)

Erratum to: In vivo role of different domains and of phosphorylation in the transcription factor Nkx2-1
por: Silberschmidt, Daniel, et al.
Publicado: (2016)

Neuropilin-2 Is a Newly Identified Target of PAX8 in Thyroid Cells
por: Lucci, Valeria, et al.
Publicado: (2015)

New insights in the interpretation of array-CGH: autism spectrum disorder and positive family history for intellectual disability predict the detection of pathogenic variants
por: Cappuccio, Gerarda, et al.
Publicado: (2016)

Assessment of radial glia in the frontal lobe of fetuses with Down syndrome
por: Baburamani, Ana A., et al.
Publicado: (2020)

Pax8 modulates the expression of Wnt4 that is necessary for the maintenance of the epithelial phenotype of thyroid cells
por: Filippone, Maria Grazia, et al.
Publicado: (2014)

Prenatal Diagnosis of Transient Abnormal Myelopoiesis in a Down Syndrome Fetus
por: Kim, Gwang Jun, et al.
Publicado: (2009)

Adaptive Brain Shut-Down Counteracts Neuroinflammation in the Near-Term Ovine Fetus
por: Xu, Alex, et al.
Publicado: (2014)

MicroRNA‐132 is overexpressed in fetuses with late‐onset fetal growth restriction
por: Morales‐Roselló, José, et al.
Publicado: (2022)

Clashes of consensus: on the problem of both justifying abortion of fetuses with Down syndrome and rejecting infanticide
por: Friberg-Fernros, Henrik
Publicado: (2017)

Genome-wide miRNA profiling in plasma of pregnant women with down syndrome fetuses
por: Zedníková, Iveta, et al.
Publicado: (2020)

Sex Differences in Protein Expression and Their Perturbations in Amniotic Fluid Cells of Down Syndrome Fetuses
por: Liu, Yanyan, et al.
Publicado: (2022)

Adaptive shut-down of EEG activity predicts critical acidemia in the near-term ovine fetus
por: Frasch, Martin G, et al.
Publicado: (2015)

Modulation by Ethanol of Cigarette Smoke Clastogenicity in Cells of Adult Mice and of Transplacentally Exposed Fetuses
por: Balansky, Roumen, et al.
Publicado: (2016)

Comment on redefining authorship in the era of artificial intelligence: balancing ethics, transparency, and progress
por: Scimeca, Manuel, et al.
Publicado: (2023)

Bioinformatics characterization of differential proteins in serum of mothers carrying Down syndrome fetuses: combining bioinformatics and ELISA
por: Yu, Bin, et al.
Publicado: (2012)

Serum amyloid-p (SAP), a potential biomarker for Down syndrome fetuses prevention in maternal plasma
por: Anagnostopoulos, Athanasios, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_pd7klfl2lp3j6470cg7icrt6g0