Influenza Virus Hemagglutinin Stalk-Specific Antibodies in Human Serum are a Surrogate Marker for In Vivo Protection in a Serum Transfer Mouse Challenge Model

The immunogenicity of current influenza virus vaccines is assessed by measuring an increase of influenza virus-specific antibodies in a hemagglutination inhibition assay. This method exclusively measures antibodies against the hemagglutinin head domain. While this domain is immunodominant, it has be...

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Detalles Bibliográficos
Autores principales: Jacobsen, Henning, Rajendran, Madhusudan, Choi, Angela, Sjursen, Haakon, Brokstad, Karl A., Cox, Rebecca J., Palese, Peter, Krammer, Florian, Nachbagauer, Raffael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605943/
https://www.ncbi.nlm.nih.gov/pubmed/28928215
http://dx.doi.org/10.1128/mBio.01463-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605943/
https://www.ncbi.nlm.nih.gov/pubmed/28928215
http://dx.doi.org/10.1128/mBio.01463-17

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