The acid-sensing ion channel, ASIC2, promotes invasion and metastasis of colorectal cancer under acidosis by activating the calcineurin/NFAT1 axis

BACKGROUND: The tumor acidic microenvironment, a common biochemical event in solid tumors, offers evolutional advantage for tumors cells and even enhances their aggressive phenotype. However, little is known about the molecular mechanism underlying the acidic microenvironment-induced invasion and me...

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Detalles Bibliográficos
Autores principales: Zhou, Zhi-hang, Song, Jin-wen, Li, Wen, Liu, Xue, Cao, Liu, Wan, Lu-ming, Tan, Ying-xia, Ji, Shou-ping, Liang, Yu-mei, Gong, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606037/
https://www.ncbi.nlm.nih.gov/pubmed/28927426
http://dx.doi.org/10.1186/s13046-017-0599-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606037/
https://www.ncbi.nlm.nih.gov/pubmed/28927426
http://dx.doi.org/10.1186/s13046-017-0599-9

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