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The acid-sensing ion channel, ASIC2, promotes invasion and metastasis of colorectal cancer under acidosis by activating the calcineurin/NFAT1 axis
BACKGROUND: The tumor acidic microenvironment, a common biochemical event in solid tumors, offers evolutional advantage for tumors cells and even enhances their aggressive phenotype. However, little is known about the molecular mechanism underlying the acidic microenvironment-induced invasion and me...
Autores principales: | Zhou, Zhi-hang, Song, Jin-wen, Li, Wen, Liu, Xue, Cao, Liu, Wan, Lu-ming, Tan, Ying-xia, Ji, Shou-ping, Liang, Yu-mei, Gong, Feng |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606037/ https://www.ncbi.nlm.nih.gov/pubmed/28927426 http://dx.doi.org/10.1186/s13046-017-0599-9 |
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