Structural analysis of BRCA1 reveals modification hotspot

Cancer cells afflicted with mutations in the breast cancer susceptibility protein (BRCA1) often suffer from increased DNA damage and genomic instability. The precise manner in which physical changes to BRCA1 influence its role in DNA maintenance remains unclear. We used single-particle electron micr...

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Detalles Bibliográficos
Autores principales: Liang, Yanping, Dearnaley, William J., Varano, A. Cameron, Winton, Carly E., Gilmore, Brian L., Alden, Nick A., Sheng, Zhi, Kelly, Deborah F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606707/
https://www.ncbi.nlm.nih.gov/pubmed/28948225
http://dx.doi.org/10.1126/sciadv.1701386

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606707/
https://www.ncbi.nlm.nih.gov/pubmed/28948225
http://dx.doi.org/10.1126/sciadv.1701386

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