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Acidic C-terminal domains autoregulate the RNA chaperone Hfq

The RNA chaperone Hfq is an Sm protein that facilitates base pairing between bacterial small RNAs (sRNAs) and mRNAs involved in stress response and pathogenesis. Hfq possesses an intrinsically disordered C-terminal domain (CTD) that may tune the function of the Sm domain in different organisms. In E...

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Detalles Bibliográficos
Autores principales: Santiago-Frangos, Andrew, Jeliazkov, Jeliazko R, Gray, Jeffrey J, Woodson, Sarah A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606850/
https://www.ncbi.nlm.nih.gov/pubmed/28826489
http://dx.doi.org/10.7554/eLife.27049