Targeting trisomic treatments: optimizing Dyrk1a inhibition to improve Down syndrome deficits

Overexpression of Dual‐specificity tyrosine‐phosphorylated regulated kinase 1A (DYRK1A), located on human chromosome 21, may alter molecular processes linked to developmental deficits in Down syndrome (DS). Trisomic DYRK1A is a rational therapeutic target, and although reductions in Dyrk1a genetic d...

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Detalles Bibliográficos
Autores principales: Stringer, Megan, Goodlett, Charles R., Roper, Randall J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606891/
https://www.ncbi.nlm.nih.gov/pubmed/28944229
http://dx.doi.org/10.1002/mgg3.334

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606891/
https://www.ncbi.nlm.nih.gov/pubmed/28944229
http://dx.doi.org/10.1002/mgg3.334

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