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Automatic and adaptive heterogeneous refractive index compensation for light-sheet microscopy

Optical tissue clearing has revolutionized researchers’ ability to perform fluorescent measurements of molecules, cells, and structures within intact tissue. One common complication to all optically cleared tissue is a spatially heterogeneous refractive index, leading to light scattering and first-o...

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Detalles Bibliográficos
Autores principales: Ryan, Duncan P., Gould, Elizabeth A., Seedorf, Gregory J., Masihzadeh, Omid, Abman, Steven H., Vijayaraghavan, Sukumar, Macklin, Wendy B., Restrepo, Diego, Shepherd, Douglas P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606987/
https://www.ncbi.nlm.nih.gov/pubmed/28931809
http://dx.doi.org/10.1038/s41467-017-00514-7