Predicting ligand-dependent tumors from multi-dimensional signaling features

Targeted therapies have shown significant patient benefit in about 5–10% of solid tumors that are addicted to a single oncogene. Here, we explore the idea of ligand addiction as a driver of tumor growth. High ligand levels in tumors have been shown to be associated with impaired patient survival, bu...

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Detalles Bibliográficos
Autores principales: Hass, Helge, Masson, Kristina, Wohlgemuth, Sibylle, Paragas, Violette, Allen, John E., Sevecka, Mark, Pace, Emily, Timmer, Jens, Stelling, Joerg, MacBeath, Gavin, Schoeberl, Birgit, Raue, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607260/
https://www.ncbi.nlm.nih.gov/pubmed/28944080
http://dx.doi.org/10.1038/s41540-017-0030-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607260/
https://www.ncbi.nlm.nih.gov/pubmed/28944080
http://dx.doi.org/10.1038/s41540-017-0030-3

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