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Circulating Mycobacterium tuberculosis DosR latency antigen-specific, polyfunctional, regulatory IL10(+) Th17 CD4 T-cells differentiate latent from active tuberculosis
The functional heterogeneity of T cell responses to diverse antigens expressed at different stages of Mycobacterium tuberculosis (Mtb) infection, in particular early secreted versus dormancy related latency antigens expressed later, that distinguish subjects with latent (LTBI), pulmonary (PTB) or ex...
Autores principales: | Rakshit, Srabanti, Adiga, Vasista, Nayak, Soumya, Sahoo, Pravat Nalini, Sharma, Prabhat Kumar, van Meijgaarden, Krista E., UK J., Anto Jesuraj, Dhar, Chirag, Souza, George D., Finak, Greg, De Rosa, Stephen C., Ottenhoff, Tom H. M., Vyakarnam, Annapurna |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607261/ https://www.ncbi.nlm.nih.gov/pubmed/28931830 http://dx.doi.org/10.1038/s41598-017-10773-5 |
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