Design, synthesis and structure-activity relationship of 3,6-diaryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines as novel tubulin inhibitors

A novel series of 3,6-diaryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines were designed, synthesized and biologically evaluated as vinylogous CA-4 analogues, which involved a rigid [1,2,4]triazolo[3,4-b][1,3,4]thiadiazine scaffold to fix the configuration of (Z,E)-butadiene linker of A-ring and B-ri...

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Detalles Bibliográficos
Autores principales: Xu, Qile, Bao, Kai, Sun, Maolin, Xu, Jingwen, Wang, Yueting, Tian, Haiqiu, Zuo, Daiying, Guan, Qi, Wu, Yingliang, Zhang, Weige
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607265/
https://www.ncbi.nlm.nih.gov/pubmed/28931885
http://dx.doi.org/10.1038/s41598-017-10860-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607265/
https://www.ncbi.nlm.nih.gov/pubmed/28931885
http://dx.doi.org/10.1038/s41598-017-10860-7

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