A Novel H2S-releasing Amino-Bisphosphonate which combines bone anti-catabolic and anabolic functions

Bisphosphonates (BPs) are the first-line treatment of bone loss resulting from various pathological conditions. Due to their high affinity to bone they have been used to develop conjugates with pro-anabolic or anti-catabolic drugs. We recently demontrated that hydrogen sulfide (H(2)S), promotes oste...

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Detalles Bibliográficos
Autores principales: Rapposelli, Simona, Gambari, Laura, Digiacomo, Maria, Citi, Valentina, Lisignoli, Gina, Manferdini, Cristina, Calderone, Vincenzo, Grassi, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607332/
https://www.ncbi.nlm.nih.gov/pubmed/28931828
http://dx.doi.org/10.1038/s41598-017-11608-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607332/
https://www.ncbi.nlm.nih.gov/pubmed/28931828
http://dx.doi.org/10.1038/s41598-017-11608-z

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