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Topological organization and dynamic regulation of human tRNA genes during macrophage differentiation

BACKGROUND: The human genome is hierarchically organized into local and long-range structures that help shape cell-type-specific transcription patterns. Transfer RNA (tRNA) genes (tDNAs), which are transcribed by RNA polymerase III (RNAPIII) and encode RNA molecules responsible for translation, are...

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Detalles Bibliográficos
Autores principales: Van Bortle, Kevin, Phanstiel, Douglas H., Snyder, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607496/
https://www.ncbi.nlm.nih.gov/pubmed/28931413
http://dx.doi.org/10.1186/s13059-017-1310-3