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VISMapper: ultra-fast exhaustive cartography of viral insertion sites for gene therapy

BACKGROUND: The possibility of integrating viral vectors to become a persistent part of the host genome makes them a crucial element of clinical gene therapy. However, viral integration has associated risks, such as the unintentional activation of oncogenes that can result in cancer. Therefore, the...

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Detalles Bibliográficos
Autores principales: Juanes, José M., Gallego, Asunción, Tárraga, Joaquín, Chaves, Felipe J., Marín-Garcia, Pablo, Medina, Ignacio, Arnau, Vicente, Dopazo, Joaquín
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607581/
https://www.ncbi.nlm.nih.gov/pubmed/28931371
http://dx.doi.org/10.1186/s12859-017-1837-z