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VISMapper: ultra-fast exhaustive cartography of viral insertion sites for gene therapy
BACKGROUND: The possibility of integrating viral vectors to become a persistent part of the host genome makes them a crucial element of clinical gene therapy. However, viral integration has associated risks, such as the unintentional activation of oncogenes that can result in cancer. Therefore, the...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607581/ https://www.ncbi.nlm.nih.gov/pubmed/28931371 http://dx.doi.org/10.1186/s12859-017-1837-z |