Enantioselective total synthesis of (–)-colchicine, (+)-demecolcinone and metacolchicine: determination of the absolute configurations of the latter two alkaloids

Here, we describe a concise, enantioselective, and scalable synthesis of (–)-colchicine (9.2% overall yield, >99% ee). Moreover, we have also achieved the first syntheses of (+)-demecolcinone and metacolchicine, and determined their absolute configurations. The challenging tricyclic 6-7-7 core of...

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Detalles Bibliográficos
Autores principales: Chen, Bo, Liu, Xin, Hu, Ya-Jian, Zhang, Dong-Mei, Deng, Lijuan, Lu, Jieyu, Min, Long, Ye, Wen-Cai, Li, Chuang-Chuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607857/
https://www.ncbi.nlm.nih.gov/pubmed/28959419
http://dx.doi.org/10.1039/c7sc01341h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607857/
https://www.ncbi.nlm.nih.gov/pubmed/28959419
http://dx.doi.org/10.1039/c7sc01341h

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