Assessment of Spontaneous Alternation, Novel Object Recognition and Limb Clasping in Transgenic Mouse Models of Amyloid-β and Tau Neuropathology

Here we describe a staged, behavioral testing approach that can be used to screen for compounds that exhibit in vivo efficacy on cognitive and functional motor behaviors in transgenic mouse models of β-amyloidosis and tauopathy. The paradigm includes tests for spontaneous alternation in a Y-maze, no...

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Detalles Bibliográficos
Autores principales: Miedel, Christian J., Patton, Jennifer M., Miedel, Andrew N., Miedel, Edward S., Levenson, Jonathan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MyJove Corporation 2017
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608159/
https://www.ncbi.nlm.nih.gov/pubmed/28605382
http://dx.doi.org/10.3791/55523

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608159/
https://www.ncbi.nlm.nih.gov/pubmed/28605382
http://dx.doi.org/10.3791/55523

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