Ursodeoxycholic acid prevents ventricular conduction slowing and arrhythmia by restoring T-type calcium current in fetuses during cholestasis

BACKGROUND: Increased maternal serum bile acid concentrations in intrahepatic cholestasis of pregnancy (ICP) are associated with fetal cardiac arrhythmias. Ursodeoxycholic acid (UDCA) has been shown to demonstrate anti-arrhythmic properties via preventing ICP-associated cardiac conduction slowing an...

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Detalles Bibliográficos
Autores principales: Adeyemi, Oladipupo, Alvarez-Laviada, Anita, Schultz, Francisca, Ibrahim, Effendi, Trauner, Michael, Williamson, Catherine, Glukhov, Alexey V., Gorelik, Julia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608194/
https://www.ncbi.nlm.nih.gov/pubmed/28934223
http://dx.doi.org/10.1371/journal.pone.0183167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608194/
https://www.ncbi.nlm.nih.gov/pubmed/28934223
http://dx.doi.org/10.1371/journal.pone.0183167

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