Amplification of the EGFR gene can be maintained and modulated by variation of EGF concentrations in in vitro models of glioblastoma multiforme

Glioblastoma multiforme (GBM) is the most common and lethal brain tumor in adults. It is known that amplification of the epidermal growth factor receptor gene (EGFR) occurs in approximately 40% of GBM, leading to enhanced activation of the EGFR signaling pathway and promoting tumor growth. Although...

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Detalles Bibliográficos
Autores principales: William, Doreen, Mokri, Poroshista, Lamp, Nora, Linnebacher, Michael, Classen, Carl Friedrich, Erbersdobler, Andreas, Schneider, Björn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608330/
https://www.ncbi.nlm.nih.gov/pubmed/28934307
http://dx.doi.org/10.1371/journal.pone.0185208

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608330/
https://www.ncbi.nlm.nih.gov/pubmed/28934307
http://dx.doi.org/10.1371/journal.pone.0185208

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