HIF-1α is a key regulator in potentiating suppressor activity and limiting the microbicidal capacity of MDSC-like cells during visceral leishmaniasis

Leishmania donovani is known to induce myelopoiesis and to dramatically increase extramedullary myelopoiesis. This results in splenomegaly, which is then accompanied by disruption of the splenic microarchitecture, a chronic inflammatory environment, and immunosuppression. Chronically inflamed tissue...

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Detalles Bibliográficos
Autores principales: Hammami, Akil, Abidin, Belma Melda, Charpentier, Tania, Fabié, Aymeric, Duguay, Annie-Pier, Heinonen, Krista M., Stäger, Simona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608422/
https://www.ncbi.nlm.nih.gov/pubmed/28892492
http://dx.doi.org/10.1371/journal.ppat.1006616

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608422/
https://www.ncbi.nlm.nih.gov/pubmed/28892492
http://dx.doi.org/10.1371/journal.ppat.1006616

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