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Exploring the inhibition mechanism of adenylyl cyclase type 5 by n-terminal myristoylated Gα(i1)
Adenylyl cyclase (AC) is an important messenger involved in G-protein-coupled-receptor signal transduction pathways, which is a well-known target for drug development. AC is regulated by activated stimulatory (Gα(s)) and inhibitory (Gα(i)) G proteins in the cytosol. Although experimental studies hav...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608429/ https://www.ncbi.nlm.nih.gov/pubmed/28892485 http://dx.doi.org/10.1371/journal.pcbi.1005673 |