Photo-affinity labelling and biochemical analyses identify the target of trypanocidal simplified natural product analogues

Current drugs to treat African sleeping sickness are inadequate and new therapies are urgently required. As part of a medicinal chemistry programme based upon the simplification of acetogenin-type ether scaffolds, we previously reported the promising trypanocidal activity of compound 1, a bis-tetrah...

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Detalles Bibliográficos
Autores principales: Tulloch, Lindsay B., Menzies, Stefanie K., Fraser, Andrew L., Gould, Eoin R., King, Elizabeth F., Zacharova, Marija K., Florence, Gordon J., Smith, Terry K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608556/
https://www.ncbi.nlm.nih.gov/pubmed/28873407
http://dx.doi.org/10.1371/journal.pntd.0005886

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608556/
https://www.ncbi.nlm.nih.gov/pubmed/28873407
http://dx.doi.org/10.1371/journal.pntd.0005886

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