Fully human CD19-specific chimeric antigen receptors for T-cell therapy

Impressive results have been achieved by adoptively transferring T-cells expressing CD19-specific CARs with binding domains from murine mAbs to treat B-cell malignancies. T-cell mediated immune responses specific for peptides from the murine scFv antigen-binding domain of the CAR can develop in pati...

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Detalles Bibliográficos
Autores principales: Sommermeyer, Daniel, Hill, Tyler, Shamah, Steven M, Salter, Alexander I, Chen, Yan, Mohler, Kendall M., Riddell, Stanley R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608623/
https://www.ncbi.nlm.nih.gov/pubmed/28202953
http://dx.doi.org/10.1038/leu.2017.57

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608623/
https://www.ncbi.nlm.nih.gov/pubmed/28202953
http://dx.doi.org/10.1038/leu.2017.57

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