Targeting Group I p21-Activated Kinases to Control Malignant Peripheral Nerve Sheath Tumor Growth and Metastasis

Malignant peripheral nerve sheath tumors (MPNSTs) are devastating sarcomas for which no effective medical therapies are available. Over 50% of MPSNTs are associated with mutations in NF1 tumor suppressor gene, resulting in activation of Ras and its effectors, including the Raf/Mek/Erk and PI3K/Akt/m...

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Detalles Bibliográficos
Autores principales: Semenova, Galina, Stepanova, Dina S., Dubyk, Cara, Handorf, Elizabeth, Deyev, Sergey M., Lazar, Alexander J., Chernoff, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608634/
https://www.ncbi.nlm.nih.gov/pubmed/28534510
http://dx.doi.org/10.1038/onc.2017.143

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608634/
https://www.ncbi.nlm.nih.gov/pubmed/28534510
http://dx.doi.org/10.1038/onc.2017.143

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