An engineered bispecific DNA-encoded IgG antibody protects against Pseudomonas aeruginosa in a pneumonia challenge model

The impact of broad-spectrum antibiotics on antimicrobial resistance and disruption of the beneficial microbiome compels the urgent investigation of bacteria-specific approaches such as antibody-based strategies. Among these, DNA-delivered monoclonal antibodies (DMAbs), produced by muscle cells in v...

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Detalles Bibliográficos
Autores principales: Patel, Ami, DiGiandomenico, Antonio, Keller, Ashley E., Smith, Trevor R. F., Park, Daniel H., Ramos, Stephanie, Schultheis, Katherine, Elliott, Sarah T. C., Mendoza, Janess, Broderick, Kate E., Wise, Megan C., Yan, Jian, Jiang, Jingjing, Flingai, Seleeke, Khan, Amir S., Muthumani, Kar, Humeau, Laurent, Cheng, Lily I., Wachter-Rosati, Leslie, Stover, C. Kendall, Sardesai, Niranjan Y., Weiner, David B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608701/
https://www.ncbi.nlm.nih.gov/pubmed/28935938
http://dx.doi.org/10.1038/s41467-017-00576-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608701/
https://www.ncbi.nlm.nih.gov/pubmed/28935938
http://dx.doi.org/10.1038/s41467-017-00576-7

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