Cargando…

An engineered bispecific DNA-encoded IgG antibody protects against Pseudomonas aeruginosa in a pneumonia challenge model

The impact of broad-spectrum antibiotics on antimicrobial resistance and disruption of the beneficial microbiome compels the urgent investigation of bacteria-specific approaches such as antibody-based strategies. Among these, DNA-delivered monoclonal antibodies (DMAbs), produced by muscle cells in v...

Descripción completa

Detalles Bibliográficos
Autores principales:	Patel, Ami, DiGiandomenico, Antonio, Keller, Ashley E., Smith, Trevor R. F., Park, Daniel H., Ramos, Stephanie, Schultheis, Katherine, Elliott, Sarah T. C., Mendoza, Janess, Broderick, Kate E., Wise, Megan C., Yan, Jian, Jiang, Jingjing, Flingai, Seleeke, Khan, Amir S., Muthumani, Kar, Humeau, Laurent, Cheng, Lily I., Wachter-Rosati, Leslie, Stover, C. Kendall, Sardesai, Niranjan Y., Weiner, David B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608701/ https://www.ncbi.nlm.nih.gov/pubmed/28935938 http://dx.doi.org/10.1038/s41467-017-00576-7

Ejemplares similares

Protection against dengue disease by synthetic nucleic acid antibody prophylaxis/immunotherapy
por: Flingai, Seleeke, et al.
Publicado: (2015)

DMAb inoculation of synthetic cross reactive antibodies protects against lethal influenza A and B infections
por: Elliott, Sarah T. C., et al.
Publicado: (2017)

HIV-1 Env DNA Vaccine plus Protein Boost Delivered by EP Expands B- and T-Cell Responses and Neutralizing Phenotype In Vivo
por: Muthumani, Kar, et al.
Publicado: (2013)

Synthetic DNA Vaccines: Improved Vaccine Potency by Electroporation and Co-Delivered Genetic Adjuvants
por: Flingai, Seleeke, et al.
Publicado: (2013)

Rapid and Long-Term Immunity Elicited by DNA-Encoded Antibody Prophylaxis and DNA Vaccination Against Chikungunya Virus
por: Muthumani, Karuppiah, et al.
Publicado: (2016)

Active Immunoprophylaxis and Vaccine Augmentations Mediated by a Novel Plasmid DNA Formulation
por: Schommer, Nina N., et al.
Publicado: (2019)

Co-Administration of Molecular Adjuvants Expressing NF-Kappa B Subunit p65/RelA or Type-1 Transactivator T-bet Enhance Antigen Specific DNA Vaccine-Induced Immunity
por: Shedlock, Devon J., et al.
Publicado: (2014)

DNA vaccination strategy targets epidermal dendritic cells, initiating their migration and induction of a host immune response
por: Smith, Trevor RF, et al.
Publicado: (2014)

Characterization of guinea pig T cell responses elicited after EP-assisted delivery of DNA vaccines to the skin
por: Schultheis, Katherine, et al.
Publicado: (2016)

Antivirulence Bispecific Monoclonal Antibody-Mediated Protection against Pseudomonas aeruginosa Ventilator-Associated Pneumonia in a Rabbit Model
por: Aguiar-Alves, Fábio, et al.
Publicado: (2022)

Multivalent DNA Vaccines as a Strategy to Combat Multiple Concurrent Epidemics: Mosquito-Borne and Hemorrhagic Fever Viruses
por: Jiang, Jingjing, et al.
Publicado: (2021)

Active immunoprophylaxis with a synthetic DNA-encoded monoclonal anti-respiratory syncytial virus scFv-Fc fusion protein confers protection against infection and durable activity
por: Schultheis, Katherine, et al.
Publicado: (2020)

Development of Novel DNA-Encoded PCSK9 Monoclonal Antibodies as Lipid-Lowering Therapeutics
por: Khoshnejad, Makan, et al.
Publicado: (2019)

A multi-head intradermal electroporation device allows for tailored and increased dose DNA vaccine delivery to the skin
por: McCoy, Jay R, et al.
Publicado: (2014)

BEAT(® )the bispecific challenge: a novel and efficient platform for the expression of bispecific IgGs
por: Moretti, Pierre, et al.
Publicado: (2013)

Elucidating the Kinetics of Expression and Immune Cell Infiltration Resulting from Plasmid Gene Delivery Enhanced by Surface Dermal Electroporation
por: Mendoza, Janess M., et al.
Publicado: (2013)

In Vivo Delivery of a DNA-Encoded Monoclonal Antibody Protects Non-human Primates against Zika Virus
por: Esquivel, Rianne N., et al.
Publicado: (2019)

Intradermal delivery of a synthetic DNA vaccine protects macaques from Middle East respiratory syndrome coronavirus
por: Patel, Ami, et al.
Publicado: (2021)

Synthetic DNA delivery by electroporation promotes robust in vivo sulfation of broadly neutralizing anti-HIV immunoadhesin eCD4-Ig
por: Xu, Ziyang, et al.
Publicado: (2018)

Designed DNA-Encoded IL-36 Gamma Acts as a Potent Molecular Adjuvant Enhancing Zika Synthetic DNA Vaccine-Induced Immunity and Protection in a Lethal Challenge Model
por: Louis, Lumena, et al.
Publicado: (2019)

Engineering IgG-Like Bispecific Antibodies—An Overview
por: Krah, Simon, et al.
Publicado: (2018)

Microbiome Modulation as a Novel Strategy to Treat and Prevent Respiratory Infections
por: Mindt, Barbara C., et al.
Publicado: (2022)

Anti-Psl Targeting of Pseudomonas aeruginosa Biofilms for Neutrophil-Mediated Disruption
por: Ray, Valerie A., et al.
Publicado: (2017)

Publisher Correction: Anti-Psl Targeting of Pseudomonas aeruginosa Biofilms for Neutrophil-Mediated Disruption
por: Ray, Valerie A., et al.
Publicado: (2018)

Tethered-variable C(L) bispecific IgG: an antibody platform for rapid bispecific antibody screening
por: Kim, Hok Seon, et al.
Publicado: (2017)

In Vivo Delivery of Synthetic Human DNA-Encoded Monoclonal Antibodies Protect against Ebolavirus Infection in a Mouse Model
por: Patel, Ami, et al.
Publicado: (2018)

Nanoparticle Vaccines: In Vivo Assembly of Nanoparticles Achieved through Synergy of Structure‐Based Protein Engineering and Synthetic DNA Generates Enhanced Adaptive Immunity (Adv. Sci. 8/2020)
por: Xu, Ziyang, et al.
Publicado: (2020)

In Vivo Assembly of Nanoparticles Achieved through Synergy of Structure‐Based Protein Engineering and Synthetic DNA Generates Enhanced Adaptive Immunity
por: Xu, Ziyang, et al.
Publicado: (2020)

Minimally invasive and surface electroporation delivery of DNA vaccines for the induction of robust humoral immune responses against HIV antigens
por: Sardesai, NY, et al.
Publicado: (2012)

Influence of the bispecific antibody IgG subclass on T cell redirection
por: Kapelski, Stephanie, et al.
Publicado: (2019)

Synthetic DNA Delivery of an Engineered Arginase Enzyme Can Modulate Specific Immunity In Vivo
por: Khoshnejad, Makan, et al.
Publicado: (2020)

Design and characterization of mouse IgG1 and IgG2a bispecific antibodies for use in syngeneic models
por: Wang, Feng, et al.
Publicado: (2019)

Induction of tier-2 neutralizing antibodies in mice with a DNA-encoded HIV envelope native like trimer
por: Xu, Ziyang, et al.
Publicado: (2022)

Novel prostate cancer immunotherapy with a DNA-encoded anti-prostate-specific membrane antigen monoclonal antibody
por: Muthumani, Kar, et al.
Publicado: (2017)

Design Principles for Bispecific IgGs, Opportunities and Pitfalls of Artificial Disulfide Bonds
por: Vaks, Lilach, et al.
Publicado: (2018)

Characterization and analysis of scFv-IgG bispecific antibody size variants
por: Cao, Mingyan, et al.
Publicado: (2018)

Dissecting the molecular basis of high viscosity of monospecific and bispecific IgG antibodies
por: Tilegenova, Cholpon, et al.
Publicado: (2019)

A new approach to produce IgG(4)-like bispecific antibodies
por: Zhao, Caizhi, et al.
Publicado: (2021)

Generation of bispecific antibodies by structure-guided redesign of IgG constant regions
por: Iwasaki, Yordkhwan W., et al.
Publicado: (2023)

YEAST SURFACE DISPLAY OF FULL-LENGTH IGG FOR ENGINEERING MONOCLONAL AND BISPECIFIC ANTIBODIES
por: Jiang, Youwei
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_dd35j6pkmg91cb5vjrmu4rqra6