A brain-targeting lipidated peptide for neutralizing RNA-mediated toxicity in Polyglutamine Diseases

Polyglutamine (PolyQ) diseases are progressive neurodegenerative disorders caused by both protein- and RNA-mediated toxicities. We previously showed that a peptidyl inhibitor, P3, which binds directly to expanded CAG RNA can inhibit RNA-induced nucleolar stress and suppress RNA-induced neurotoxicity...

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Detalles Bibliográficos
Autores principales: Zhang, Qian, Yang, Mengbi, Sørensen, Kasper K., Madsen, Charlotte S., Boesen, Josephine T., An, Ying, Peng, Shao Hong, Wei, Yuming, Wang, Qianwen, Jensen, Knud J., Zuo, Zhong, Chan, Ho Yin Edwin, Ngo, Jacky Chi Ki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608758/
https://www.ncbi.nlm.nih.gov/pubmed/28935901
http://dx.doi.org/10.1038/s41598-017-11695-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608758/
https://www.ncbi.nlm.nih.gov/pubmed/28935901
http://dx.doi.org/10.1038/s41598-017-11695-y

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