Aromatic side-chain conformational switch on the surface of the RNA Recognition Motif enables RNA discrimination

The cyclooxygenase-2 is a pro-inflammatory and cancer marker, whose mRNA stability and translation is regulated by the CUG-binding protein 2 interacting with AU-rich sequences in the 3′ untranslated region. Here, we present the solution NMR structure of CUG-binding protein 2 RRM3 in complex with 5′-...

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Detalles Bibliográficos
Autores principales: Diarra dit Konté, Nana, Krepl, Miroslav, Damberger, Fred F., Ripin, Nina, Duss, Olivier, Šponer, Jiří, Allain, Frédéric H.-T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608764/
https://www.ncbi.nlm.nih.gov/pubmed/28935965
http://dx.doi.org/10.1038/s41467-017-00631-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608764/
https://www.ncbi.nlm.nih.gov/pubmed/28935965
http://dx.doi.org/10.1038/s41467-017-00631-3

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