Stepwise Evolution Improves Identification of Diverse Peptides Binding to a Protein Target

Considerable efforts have been made to develop technologies for selection of peptidic molecules that act as substrates or binders to a protein of interest. Here we demonstrate the combination of rational peptide array library design, parallel screening and stepwise evolution, to discover novel pepti...

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Detalles Bibliográficos
Autores principales: Lyamichev, Victor I., Goodrich, Lauren E., Sullivan, Eric H., Bannen, Ryan M., Benz, Joerg, Albert, Thomas J., Patel, Jigar J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608804/
https://www.ncbi.nlm.nih.gov/pubmed/28935886
http://dx.doi.org/10.1038/s41598-017-12440-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608804/
https://www.ncbi.nlm.nih.gov/pubmed/28935886
http://dx.doi.org/10.1038/s41598-017-12440-1

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