Glycogen Synthase Kinase-3β Inhibition Links Mitochondrial Dysfunction, Extracellular Matrix Remodelling and Terminal Differentiation in Chondrocytes

Following inflammatory stimuli, GSK3 inhibition functions as a hub with pleiotropic effects leading to cartilage degradation. However, little is known about the effects triggered by its direct inhibition as well as the effects on mitochondrial pathology, that contributes to osteoarthritis pathogenes...

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Detalles Bibliográficos
Autores principales: Guidotti, S., Minguzzi, M., Platano, D., Santi, S., Trisolino, G., Filardo, G., Mariani, E., Borzì, R. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608843/
https://www.ncbi.nlm.nih.gov/pubmed/28935982
http://dx.doi.org/10.1038/s41598-017-12129-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608843/
https://www.ncbi.nlm.nih.gov/pubmed/28935982
http://dx.doi.org/10.1038/s41598-017-12129-5

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