Inhibition of PDE2 reverses beta amyloid induced memory impairment through regulation of PKA/PKG-dependent neuro-inflammatory and apoptotic pathways

Beta amyloid peptides (Aβ) are known risk factors involved in cognitive impairment, neuroinflammatory and apoptotic processes in Alzheimer’s disease (AD). Phosphodiesterase 2 (PDE2) inhibitors increase the intracellular cAMP and/or cGMP activities, which may ameliorate cognitive deficits associated...

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Detalles Bibliográficos
Autores principales: Wang, Li, Xiaokaiti, Yilixiati, Wang, Gang, Xu, Xiaoxiao, Chen, Ling, Huang, Xianfeng, Liu, Li, Pan, Jianchun, Hu, Shuqun, Chen, Zhuoyou, Xu, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608906/
https://www.ncbi.nlm.nih.gov/pubmed/28935920
http://dx.doi.org/10.1038/s41598-017-08070-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608906/
https://www.ncbi.nlm.nih.gov/pubmed/28935920
http://dx.doi.org/10.1038/s41598-017-08070-2

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