Novel scaffolds for inhibition of Cruzipain identified from high-throughput screening of anti-kinetoplastid chemical boxes

American Trypanosomiasis or Chagas disease is a prevalent, neglected and serious debilitating illness caused by the kinetoplastid protozoan parasite Trypanosoma cruzi. The current chemotherapy is limited only to nifurtimox and benznidazole, two drugs that have poor efficacy in the chronic phase and...

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Detalles Bibliográficos
Autores principales: Salas-Sarduy, Emir, Landaburu, Lionel Urán, Karpiak, Joel, Madauss, Kevin P., Cazzulo, Juan José, Agüero, Fernán, Alvarez, Vanina Eder
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608908/
https://www.ncbi.nlm.nih.gov/pubmed/28935948
http://dx.doi.org/10.1038/s41598-017-12170-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608908/
https://www.ncbi.nlm.nih.gov/pubmed/28935948
http://dx.doi.org/10.1038/s41598-017-12170-4

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