Functional Insights into ANP32A-Dependent Influenza A Virus Polymerase Host Restriction

Host restriction of influenza A virus limits pandemic emergence. The viral RNA polymerase (vPol) is an essential enzyme that must adapt for avian viruses to replicate in humans. Species differences in host ANP32A dictate adaptation: human ANP32A lacks an uncharacterized 33 amino-acid insertion that...

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Detalles Bibliográficos
Autores principales: Domingues, Patricia, Hale, Benjamin G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608968/
https://www.ncbi.nlm.nih.gov/pubmed/28903035
http://dx.doi.org/10.1016/j.celrep.2017.08.061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608968/
https://www.ncbi.nlm.nih.gov/pubmed/28903035
http://dx.doi.org/10.1016/j.celrep.2017.08.061

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