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Functional Insights into ANP32A-Dependent Influenza A Virus Polymerase Host Restriction
Host restriction of influenza A virus limits pandemic emergence. The viral RNA polymerase (vPol) is an essential enzyme that must adapt for avian viruses to replicate in humans. Species differences in host ANP32A dictate adaptation: human ANP32A lacks an uncharacterized 33 amino-acid insertion that...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cell Press
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608968/ https://www.ncbi.nlm.nih.gov/pubmed/28903035 http://dx.doi.org/10.1016/j.celrep.2017.08.061 |