Selective inhibition of PfA-M1, over PfA-M17, by an amino-benzosuberone derivative blocks malaria parasites development in vitro and in vivo

BACKGROUND: Plasmodium falciparum M1 family aminopeptidase is currently considered as a promising target for anti-malarial chemotherapy. Several series of inhibitors developed by various research groups display IC50/Ki values down to nM range on native PfA-M1 or recombinant forms and block the paras...

Descripción completa

Detalles Bibliográficos
Autores principales: Bounaadja, Lotfi, Schmitt, Marjorie, Albrecht, Sébastien, Mouray, Elisabeth, Tarnus, Céline, Florent, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609037/
https://www.ncbi.nlm.nih.gov/pubmed/28934959
http://dx.doi.org/10.1186/s12936-017-2032-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609037/
https://www.ncbi.nlm.nih.gov/pubmed/28934959
http://dx.doi.org/10.1186/s12936-017-2032-4

Ejemplares similares