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Kinetic Analysis Reveals the Identity of Aβ-Metal Complex Responsible for the Initial Aggregation of Aβ in the Synapse

[Image: see text] The mechanism of Aβ aggregation in the absence of metal ions is well established, yet the role that Zn(2+) and Cu(2+), the two most studied metal ions, released during neurotransmission, paly in promoting Aβ aggregation in the vicinity of neuronal synapses remains elusive. Here we...

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Detalles Bibliográficos
Autores principales: Branch, Thomas, Barahona, Mauricio, Dodson, Charlotte A., Ying, Liming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609119/
https://www.ncbi.nlm.nih.gov/pubmed/28621929
http://dx.doi.org/10.1021/acschemneuro.7b00121