Cargando…

Synthesis and Evaluation of New Fluorine-18 Labeled Verapamil Analogs To Investigate the Function of P-Glycoprotein in the Blood–Brain Barrier

[Image: see text] P-glycoprotein is an efflux transporter located in the blood–brain barrier. (R)-[(11)C]Verapamil is widely used as a PET tracer to investigate its function in patients with epilepsy, Alzheimer’s disease, and other neurodegenerative diseases. Currently it is not possible to use this...

Descripción completa

Detalles Bibliográficos
Autores principales:	Raaphorst, Renske M., Luurtsema, Gert, Schuit, Robert C., Kooijman, Esther J. M., Elsinga, Philip H., Lammertsma, Adriaan A., Windhorst, Albert D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2017
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609126/ https://www.ncbi.nlm.nih.gov/pubmed/28650628 http://dx.doi.org/10.1021/acschemneuro.7b00086

Ejemplares similares

Comparison of In Vitro Assays in Selecting Radiotracers for In Vivo P-Glycoprotein PET Imaging
por: Raaphorst, Renske M., et al.
Publicado: (2017)

(R)-[(11)C]Verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus
por: Syvänen, Stina, et al.
Publicado: (2011)

Synthesis and preliminary preclinical evaluation of fluorine-18 labelled isatin-4-(4-methoxyphenyl)-3-thiosemicarbazone ([(18)F]4FIMPTC) as a novel PET tracer of P-glycoprotein expression
por: Verbeek, Joost, et al.
Publicado: (2018)

Reproducibility of quantitative (R)-[(11)C]verapamil studies
por: van Assema, Daniëlle ME, et al.
Publicado: (2012)

Pharmacokinetic Modeling of (R)-[(11)C]verapamil to Measure the P-Glycoprotein Function in Nonhuman Primates
por: García-Varela, Lara, et al.
Publicado: (2020)

Quantification of P-glycoprotein function at the human blood-brain barrier using [(18)F]MC225 and PET
por: Mossel, Pascalle, et al.
Publicado: (2023)

Head-to-head comparison of (R)-[(11)C]verapamil and [(18)F]MC225 in non-human primates, tracers for measuring P-glycoprotein function
por: García-Varela, Lara, et al.
Publicado: (2021)

Evaluation of P-glycoprotein function at the blood–brain barrier using [(18)F]MC225-PET
por: Mossel, Pascalle, et al.
Publicado: (2021)

P-Glycoprotein Function at the Blood–Brain Barrier: Effects of Age and Gender
por: van Assema, Daniëlle M. E., et al.
Publicado: (2012)

Evaluation of Tracer Kinetic Models for Analysis of [(18)F]FDDNP Studies
por: Yaqub, Maqsood, et al.
Publicado: (2009)

Pharmacokinetic Modeling of [(18)F]MC225 for Quantification of the P-Glycoprotein Function at the Blood–Brain Barrier in Non-Human Primates with PET
por: García-Varela, Lara, et al.
Publicado: (2020)

Automated synthesis, preclinical toxicity, and radiation dosimetry of [(18)F]MC225 for clinical use: a tracer for measuring P-glycoprotein function at the blood-brain barrier
por: Toyohara, Jun, et al.
Publicado: (2020)

In Vivo Induction of P-Glycoprotein Function can be Measured with [(18)F]MC225 and PET
por: García-Varela, Lara, et al.
Publicado: (2021)

Test-retest variability of quantitative [(11)C]PIB studies in Alzheimer’s disease
por: Tolboom, Nelleke, et al.
Publicado: (2009)

Differential Labeling of Glycoproteins with Alkynyl Fucose Analogs
por: Ma, Chenyu, et al.
Publicado: (2020)

Verapamil and Rifampin Effect on P-Glycoprotein Expression in Hepatocellular Carcinoma
por: Jalali, Amir, et al.
Publicado: (2014)

Fluorine-18 Labeled Fluorofuranylnorprogesterone ([(18)F]FFNP) and Dihydrotestosterone ([(18)F]FDHT) Prepared by “Fluorination on Sep-Pak” Method
por: Basuli, Falguni, et al.
Publicado: (2019)

Fluorine-18 Radiochemistry, Labeling Strategies and Synthetic Routes
por: Jacobson, Orit, et al.
Publicado: (2014)

Blood–brain barrier P-glycoprotein function in healthy subjects and Alzheimer's disease patients: effect of polymorphisms in the ABCB1 gene
por: van Assema, Daniëlle ME, et al.
Publicado: (2012)

Approaching complete inhibition of P-glycoprotein at the human blood–brain barrier: an (R)-[(11)C]verapamil PET study
por: Bauer, Martin, et al.
Publicado: (2015)

Fluorine-18 Labelled Radioligands for PET Imaging of Cyclooxygenase-2
por: Kaur, Jatinder, et al.
Publicado: (2022)

Synthesis and Evaluation of Fluorine-18-Labeled L-Rhamnose Derivatives
por: Zhang, Xiang, et al.
Publicado: (2023)

Quantification of O-(2-[(18)F]fluoroethyl)-L-tyrosine kinetics in glioma
por: Koopman, Thomas, et al.
Publicado: (2018)

(R)-[(11)C]verapamil is selectively transported by murine and human P-glycoprotein at the blood–brain barrier, and not by MRP1 and BCRP
por: Römermann, Kerstin, et al.
Publicado: (2013)

Imaging the TGFβ type I receptor in pulmonary arterial hypertension
por: Rotteveel, Lonneke, et al.
Publicado: (2023)

Fluorine-18 labeled amino acids for tumor PET/CT imaging
por: Qi, Yiqiang, et al.
Publicado: (2017)

Fluorine-18-Labeled Fluorescent Dyes for Dual-Mode Molecular Imaging
por: Munch, Maxime, et al.
Publicado: (2020)

[(18)F]Atorvastatin Pharmacokinetics and Biodistribution in Healthy Female and Male Rats
por: Clemente, Gonçalo S., et al.
Publicado: (2021)

Synthesis of Substituted Benzaldehydes via a Two-Step, One-Pot Reduction/Cross-Coupling Procedure
por: Heijnen, Dorus, et al.
Publicado: (2019)

Dose-response assessment of tariquidar for inhibition of P-glycoprotein at the human blood-brain barrier using (R)-[(11)C]verapamil PET
por: Bauer, Martin, et al.
Publicado: (2010)

In vivo evaluation of two tissue transglutaminase PET tracers in an orthotopic tumour xenograft model
por: van der Wildt, Berend, et al.
Publicado: (2018)

Evaluation of Fluorine-18-Labeled α1(I)-N-Telopeptide Analogs as Substrate-Based Radiotracers for PET Imaging of Melanoma-Associated Lysyl Oxidase
por: Kuchar, Manuela, et al.
Publicado: (2018)

Unravelling the complex drug–drug interactions of the cardiovascular drugs, verapamil and digoxin, with P-glycoprotein
por: Ledwitch, Kaitlyn V., et al.
Publicado: (2016)

Synthesis and Preclinical Evaluation of the First Carbon-11 Labeled PET Tracers Targeting Substance P(1–7)
por: Pekošak, Aleksandra, et al.
Publicado: (2018)

Fluorinated Analogs of Malachite Green: Synthesis and Toxicity
por: Kraus, George A., et al.
Publicado: (2008)

Verapamil in Diabetes
por: Poudel, Resham Raj, et al.
Publicado: (2017)

Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain
por: Syvänen, Stina, et al.
Publicado: (2020)

Pharmacokinetic modeling of P-glycoprotein function at the rat and human blood–brain barriers studied with (R)-[(11)C]verapamil positron emission tomography
por: Müllauer, Julia, et al.
Publicado: (2012)

MCR Scaffolds Get Hotter with (18)F-Labeling
por: Zarganes-Tzitzikas, Tryfon, et al.
Publicado: (2019)

Mechanistic study of nucleophilic fluorination for the synthesis of fluorine-18 labeled fluoroform with high molar activity from N-difluoromethyltriazolium triflate
por: Chai, Jin Young, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_r96mqlr5di1dme7gk15cqpiulq