Progranulin acts as a shared chaperone and regulates multiple lysosomal enzymes

Multifunctional factor progranulin (PGRN) plays an important role in lysosomes, and its mutations and insufficiency are associated with lysosomal storage diseases, including neuronal ceroid lipofuscinosis and Gaucher disease (GD). The first breakthrough in understanding the molecular mechanisms of P...

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Detalles Bibliográficos
Autores principales: Jian, Jinlong, Hettinghouse, Aubryanna, Liu, Chuan-ju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609500/
https://www.ncbi.nlm.nih.gov/pubmed/28944282
http://dx.doi.org/10.1016/j.gendis.2017.05.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609500/
https://www.ncbi.nlm.nih.gov/pubmed/28944282
http://dx.doi.org/10.1016/j.gendis.2017.05.001

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