Norborn-2-en-7-ones as physiologically-triggered carbon monoxide-releasing prodrugs

A prodrug strategy for the release of the gasotransmitter CO at physiological pH, based upon 3a-bromo-norborn-2-en-7-one Diels–Alder cycloadducts of 2-bromomaleimides and 2,5-dimethyl-3,4-diphenylcyclopentadienone has been developed. Examples possessing protonated amine and diamine groups showed goo...

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Detalles Bibliográficos
Autores principales: Kueh, Jui Thiang Brian, Stanley, Nathan J., Hewitt, Russell J., Woods, Laura M., Larsen, Lesley, Harrison, Joanne C., Rennison, David, Brimble, Margaret A., Sammut, Ivan A., Larsen, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609517/
https://www.ncbi.nlm.nih.gov/pubmed/28970925
http://dx.doi.org/10.1039/c7sc01647f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609517/
https://www.ncbi.nlm.nih.gov/pubmed/28970925
http://dx.doi.org/10.1039/c7sc01647f

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