Lysosomal Ca(2+) Signaling Regulates High Glucose-Mediated Interleukin-1β Secretion via Transcription Factor EB in Human Monocytic Cells

Aberrant activation of the innate immune system, including NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome-dependent interleukin-1β (IL-1β) secretion, has been implicated in the pathogenesis of type 2 diabetes mellitus (T2DM) and its complication. Our previous study demonstrated tha...

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Detalles Bibliográficos
Autores principales: Tseng, Hisa Hui Ling, Vong, Chi Teng, Kwan, Yiu Wa, Lee, Simon Ming-Yuen, Hoi, Maggie Pui Man
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609581/
https://www.ncbi.nlm.nih.gov/pubmed/28970837
http://dx.doi.org/10.3389/fimmu.2017.01161

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609581/
https://www.ncbi.nlm.nih.gov/pubmed/28970837
http://dx.doi.org/10.3389/fimmu.2017.01161

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